A Novel Possible Strategy Based on Self-Assembly Approach to Achieve Cementum/Periodontal-ligament Complex Regeneration

Introduction Periodontal tissue is a complete and complex system not only includes cementum/periodontal complex, but also periodontal/alveolar complex which is more significant for tooth regeneration. Numerous therapeutic measures have been utilized over the years in an attempt to achieve predicable periodontal regeneration. However, limitations of current regeneration modalities in both predictability and extent of healing response, that is failure to fully restore the various compartments of the original periodontium. Recently, it has been proposed that bone marrow mesenchymal stem cells (BMMSCs) are very likely another cell source of physiological repair of periodontal tissues. We proposed a possible strategy based on self-assembly approach, which is akin to the physiological phenomenon that occurs during organogenesis, to enhance complete reconstruction of functional complex periodontium-organ systems.